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Gaucher's Disease Mutation Explanation
The viewer helps interpret the mutation present in Gaucher's Disease. The correct amino acid for this protein at amino acid position 444 is Leucine, and in the affected protein it is changed to Proline. Shown are two monomers of the protein; initially, one is dark green; the other is colored to reflect secondary structure.

  

Amino Acid Feels Colorize by Secondary Structure

1 monomer only

Center Leu 444 (dark, medium sized) &
near amino acid neighbors (backbone small; sidechain light and large)*

Center Leu 444 (dark, medium sized) &
near amino acid neighbors (backbone small; sidechain light and large)*; ~~~Slab

Hydrophobic vs. Hydrophilic Residues+

Hydrophobic vs. Hydrophilic Residues+ (Spacefill)

Hydrophobic vs. Hydrophilic Residues+
      (Spacefill w/ Leu 444 selected; ~~~SLAB)

Hydrophobic vs. Hydrophilic Residues+
      (Spacefill w/ Leu 444 centered; ~~~SLAB)