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| Unit | Page | Brief description | Worksheet/Questions | Aspects |
|---|---|---|---|---|
| A1 | Looking in 3D | Presents ribbon, spacefill, ball-and-stick | None--tutorial | Manipulating 3D images |
| A2 | Parts and Whole | Protein to amino acid scaling | None--tutorial | scale |
| A3 | Inside/Outside | Looks at correlation btw amino acid sidechain properties and location in protein | (Which amino acids are 'inside' vs. on the surface?) | hydrophobicity, structure |
| A4 | Heme itself | The heme group, its components and | Different representations of heme, with clear views of iron, oxygen | hydrophobicity, structure |
| A5 | On the Move | Movements arising from O2 binding | (What parts of hemoglobin shift on O2 binding?) | heme, oxygen, conformation |
| A6 | Pulling together | Specific interactions that stabilize each conformation | (which amino acids interact in O2 vs. non-O2 states?) | heme, oxygen, conformation |
| B | BPG: molecular modifier | BPG (v.2.0 completed!) | (which amino acids contribute to BPG binding? What is its effect & why?) | BPG, fetal hemoglobin, O2 release, adaptations |
| C1 | Sickle cell: the mutation | the Val6 to Glu6 change | mutation, amino acid, hydrophobicity | |
| C2 | Sickle: A dangerous pocket | A pre-existing hydrophobic 'cave' | amino acid, hydrophobicity | |
| C3 | Sickle: an unwelcome polymer | Tetramer to octamer to... sickled cell | disease | |
| D | Hemoglobinopathies: Real mutations; real people | Other single amino acid changes known to occur | disease, structure-function, hypothesis |