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TP53 Disease Mutation Explanation
The viewer helps interpret the mutation present in p53 disorder. The correct amino acid for this protein at amino acid position 270 is Phenylalanine, and in the hypothetical mutant it is changed to Serine. The initial view shows 2 monomers of the p53 protein and a molecule of DNA.

Phenylalanine vs. Serine



2˚ Structure

Spacefill

Phe 270, with DNA

Neighbors Phe 270 with near amino acid neighbors (their sidechain carbons light green)

Hydrophobic [silver] vs. Hydrophilic [orchid] Residues (Ribbon)

Hydrophobic [silver] vs. Hydrophilic Residues+;(Spacefill w/ Phe 270 indicated)

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*To discover atom/amino acid identity, hover the mouse over it. Amino acids will show up using 3-letter code (i.e. [GLY] = glycine); DNA thymine= [DT]

General Instructions: For access to JMOL commands, right click (Mac Users:Hold down control key and click) in the structure display area