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TP53 Mutant Explanation
The viewer helps interpret the mutation present in p53 disorder. The correct amino acid for this protein at the exact amino acid position 273 is Arginine, and in the affected protein it is changed to Histidine. The initial view shows 2 monomers of the p53 protein and a molecule of DNA.

Arginine vs. Histidine

2˚ structure


Arg 273 and DNA

Neighbors Arg 273 as green (spacefilled; no DNA)*

Neighbors Arg 273 (light) & near neighbors*
Note: charge and atom labels are always at the 'front', so move the model around to be sure what is being labeled!

Neighbors Arg 273 in White, spacefill protein, DNA in green

Hydrophobic [silver] vs. Hydrophilic [orchid] Residues (ribbons); DNA orange

Hydrophobic [silver] vs. Hydrophilic Residues+ (Spacefill)


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*To discover atom/amino acid identity, hover the mouse over it. Amino acids will show up using 3-letter code (i.e. [GLY] = glycine); DNA thymine= [DT] .; RNA thymine= [RT].

General Instructions: For access to JMOL commands, right click (Mac Users:Hold down control key and click) in the structure display area