PGP crystal 3G60 (Mouse, Mus musculus)
Use this page for the hypothetical mutation assignment. Thu buttons allow you to label some areas of 'conspicuous interest' based on previous findings. Verapamil, QZ59-RRR and QZ59-SSS are all substrates of PGP, and the labeled amino acids closely approach them when co-crystalized. The 'antibody' referred to blocks pumping when attached... but antibodies are huge, so it's not fully clear how to interpret that. Other indicated domains are involved in ATP binding.
Use this page for the hypothetical mutation assignment. Thu buttons allow you to label some areas of 'conspicuous interest' based on previous findings. Verapamil, QZ59-RRR and QZ59-SSS are all substrates of PGP, and the labeled amino acids closely approach them when co-crystalized. The 'antibody' referred to blocks pumping when attached... but antibodies are huge, so it's not fully clear how to interpret that. Other indicated domains are involved in ATP binding.
References
Crystal structure with drugs
Antibody