Explore the pairing of bases

Module and Area columns can be sorted by clicking their headers

Sort Title Brief description Clickable
1 One DNA strand The 'informative' base faces of 5'-C-A-A-T-3' Launch
2 Assign partial charges The bases interact through the partial (+) and (-) on their faces. Can you I.D. them? Launch
4 Explore GC What must be done to orient cytosine to 'match' with guanine? Launch
4 AT paired up Pre-rolled Ade-Thy all matched up Launch
4 AU paired up Pre-rolled Ade-Ura all matched up Launch
4 AC No go NON-pairing is just as important. Look at Ade-Cyt Launch
4 GT No go... but! G and T face off poorly... but can you help them find a way (it happens in wobble!) Launch
4 Snap out of it Several of the bases have 'tautomers'--forms they visit. What changes when G tautomerizes? Launch
4 Gua's tautomer When Gua is in its tautomeric form... how does the coupling with Ura go? Launch
4 Cyt's tautomer When Cyt is in its tautomeric form... how does the coupling with Ade go? Launch
4 Uh-oh: what water vs. Cyt Several of the bases can 'deaminate'; when cytosine does, it become...uracil! Launch
4 Bad boy inosine Water turns adenine to the darks side--it's now inosine Launch
10 How does T differ from U? DNA uses thymine; RNA uses uracil. Is the difference basepairing? (answer) Launch
10 What if we allow some 'wobbling'? Crick pointed out that more pairings were possible if the bases could 'slide' relative to each other... and as he suggested, this allowed for economies in tRNA production. Examine inosine's pairing with C, U, A (G:T pairing can be explored above Launch